Two sample MR report

Telomere_length against aparc-DKTatlas lh area entorhinal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0646537	0.1328123	0.6314390
Weighted median	23	-0.1035535	0.0558248	0.0636002
Inverse variance weighted	23	-0.0878955	0.0507501	0.0832864
Simple mode	23	-0.0353491	0.0843731	0.6793061
Weighted mode	23	-0.0894981	0.0583155	0.1391090

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	37.48572	21	0.0147962
Inverse variance weighted	37.55024	22	0.0205676

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.001427	0.0075062	0.8510451

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.001293	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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