Two sample MR report

Telomere_length against aparc-DKTatlas lh area cuneus

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0173454	0.1268953	0.8925775
Weighted median	23	-0.0458259	0.0603019	0.4472899
Inverse variance weighted	23	-0.0022969	0.0484667	0.9622009
Simple mode	23	-0.1651244	0.1166608	0.1709454
Weighted mode	23	-0.1575328	0.0910587	0.0976343

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	34.22142	21	0.0343095
Inverse variance weighted	34.24847	22	0.0463390

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.000924	0.0071718	0.8987153

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010379	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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