Two sample MR report

Telomere_length against aparc-DKTatlas lh area caudalmiddlefrontal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0819093	0.0994059	0.4192069
Weighted median	23	-0.0994822	0.0550930	0.0709629
Inverse variance weighted	23	-0.1062083	0.0388451	0.0062542
Simple mode	23	-0.1530639	0.0911858	0.1073809
Weighted mode	23	-0.1032757	0.0569428	0.0833932

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.77722	21	0.599429
Inverse variance weighted	18.84774	22	0.654711

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.001492	0.0056182	0.7931687

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007977	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8