Two sample MR report

Telomere_length against aparc-DKTatlas lh area caudalanteriorcingulate

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1465896	0.1069029	0.1847764
Weighted median	23	-0.0382070	0.0584218	0.5131219
Inverse variance weighted	23	-0.0737122	0.0454247	0.1046460
Simple mode	23	-0.1173274	0.1025354	0.2648124
Weighted mode	23	-0.0226204	0.0639718	0.7270057

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.28657	21	0.2793815
Inverse variance weighted	30.08311	22	0.1164582

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0135264	0.0060418	0.0361283

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010207	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8