Two sample MR report

Telomere_length against ThalamNuclei rh volume Whole-thalamus

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0490686	0.0994061	0.6266998
Weighted median	23	0.0149008	0.0550952	0.7868098
Inverse variance weighted	23	0.0049764	0.0388455	0.8980640
Simple mode	23	0.0495232	0.0982110	0.6190966
Weighted mode	23	-0.0178034	0.0620617	0.7768996

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.94522	21	0.6524680
Inverse variance weighted	18.29408	22	0.6884168

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0033183	0.0056182	0.5610634

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005549	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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