Two sample MR report

Telomere_length against ThalamNuclei rh volume VPL

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0041751	0.0994062	0.9668954
Weighted median	23	-0.0046486	0.0529459	0.9300360
Inverse variance weighted	23	-0.0190067	0.0388455	0.6246369
Simple mode	23	-0.0264867	0.0801842	0.7442812
Weighted mode	23	-0.0151042	0.0601345	0.8040110

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.29081	21	0.6933342
Inverse variance weighted	17.31708	22	0.7456241

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0009107	0.0056182	0.8727838

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000532	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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