Two sample MR report

Telomere_length against ThalamNuclei rh volume VM

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0491709	0.1058300	0.6469836
Weighted median	23	-0.0226598	0.0537379	0.6732641
Inverse variance weighted	23	-0.0317340	0.0404357	0.4325704
Simple mode	23	-0.0029471	0.0930230	0.9750115
Weighted mode	23	-0.0239337	0.0637217	0.7108134

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.80186	21	0.3027578
Inverse variance weighted	23.83817	22	0.3557689

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0010706	0.0059812	0.8596565

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007425	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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