Two sample MR report

Telomere_length against ThalamNuclei rh volume VLp

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0808475	0.0994052	0.4251650
Weighted median	23	-0.0182399	0.0536822	0.7340247
Inverse variance weighted	23	-0.0090357	0.0388453	0.8160658
Simple mode	23	0.0353518	0.0857558	0.6841544
Weighted mode	23	-0.0384145	0.0625472	0.5454032

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.84409	21	0.5951407
Inverse variance weighted	19.46003	22	0.6167758

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0044092	0.0056181	0.4413243

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005913	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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