Two sample MR report

Telomere_length against ThalamNuclei rh volume VLa

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1545381	0.0994050	0.1349763
Weighted median	23	-0.0769525	0.0555941	0.1663020
Inverse variance weighted	23	-0.0241579	0.0388453	0.5340079
Simple mode	23	-0.0193756	0.0898104	0.8311792
Weighted mode	23	-0.0577448	0.0683987	0.4076230

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.82689	21	0.6599310
Inverse variance weighted	19.85726	22	0.5919683

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0080053	0.0056181	0.1688771

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006134	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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