Two sample MR report

Telomere_length against ThalamNuclei rh volume VAmc

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0302825	0.1122331	0.7899339
Weighted median	23	-0.0202089	0.0594291	0.7338189
Inverse variance weighted	23	-0.0072424	0.0429005	0.8659384
Simple mode	23	0.0377588	0.1089779	0.7322730
Weighted mode	23	-0.0423594	0.0857784	0.6263255

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.77009	21	0.1785935
Inverse variance weighted	26.83349	22	0.2176191

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0014147	0.0063432	0.8256742

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008141	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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