Two sample MR report

Telomere_length against ThalamNuclei rh volume VA

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2210917	0.0994043	0.0372374
Weighted median	23	-0.0559069	0.0570107	0.3267716
Inverse variance weighted	23	-0.0370782	0.0413664	0.3700722
Simple mode	23	0.0287342	0.0980720	0.7722747
Weighted mode	23	-0.0888328	0.0735416	0.2399016

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.90419	21	0.4648086
Inverse variance weighted	24.94860	22	0.2995389

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0112984	0.0056181	0.0573298

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007836	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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