Two sample MR report

Telomere_length against ThalamNuclei rh volume PuM

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0186924	0.1083046	0.8646254
Weighted median	23	0.0644636	0.0604784	0.2864711
Inverse variance weighted	23	0.0258212	0.0413546	0.5323751
Simple mode	23	0.0584474	0.1025511	0.5744969
Weighted mode	23	0.0678720	0.0746116	0.3728548

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.92817	21	0.2502883
Inverse variance weighted	24.93424	22	0.3002296

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0004377	0.0061211	0.9436706

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007689	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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