Two sample MR report

Telomere_length against ThalamNuclei rh volume PuL

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2369183	0.0994060	0.0266768
Weighted median	23	-0.0974763	0.0550983	0.0768712
Inverse variance weighted	23	-0.0634880	0.0397299	0.1100450
Simple mode	23	-0.1000615	0.0867643	0.2611817
Weighted mode	23	-0.1000615	0.0588556	0.1032048

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.42093	21	0.5581574
Inverse variance weighted	23.01337	22	0.4009749

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0106486	0.0056182	0.0718917

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007783	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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