Two sample MR report

Telomere_length against ThalamNuclei rh volume PuI

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0105037	0.1275977	0.9351727
Weighted median	23	0.0081748	0.0581905	0.8882775
Inverse variance weighted	23	-0.0053845	0.0487178	0.9119933
Simple mode	23	0.0165701	0.1049470	0.8759833
Weighted mode	23	-0.0140608	0.0802370	0.8624928

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	34.60103	21	0.0312146
Inverse variance weighted	34.60416	22	0.0425946

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0003143	0.0072115	0.9656467

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010491	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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