Two sample MR report

Telomere_length against ThalamNuclei rh volume PuA

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1436227	0.0994060	0.1632683
Weighted median	23	0.0424567	0.0594084	0.4748200
Inverse variance weighted	23	0.0043460	0.0401956	0.9138997
Simple mode	23	0.0321166	0.0991736	0.7491160
Weighted mode	23	0.0292938	0.0781346	0.7113137

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.94108	21	0.4625478
Inverse variance weighted	23.55612	22	0.3709187

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0090852	0.0056182	0.120778

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007142	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8