Two sample MR report

Telomere_length against ThalamNuclei rh volume Pt

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0277027	0.1153958	0.8126066
Weighted median	23	0.0160408	0.0548491	0.7699400
Inverse variance weighted	23	0.0053070	0.0441034	0.9042218
Simple mode	23	0.0239313	0.0952052	0.8038647
Weighted mode	23	-0.0046690	0.0606781	0.9393615

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.29920	21	0.1318678
Inverse variance weighted	28.35911	22	0.1640833

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0013751	0.0065219	0.835043

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008599	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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