Two sample MR report

Telomere_length against ThalamNuclei rh volume Pf

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0199041	0.1478532	0.8941937
Weighted median	23	-0.0262343	0.0581285	0.6517622
Inverse variance weighted	23	-0.0099047	0.0564560	0.8607331
Simple mode	23	0.0240073	0.0985264	0.8097487
Weighted mode	23	-0.0406845	0.0599269	0.5042800

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	46.45765	21	0.0011104
Inverse variance weighted	46.46959	22	0.0017200

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.000614	0.0083562	0.9421253

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0014099	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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