Two sample MR report

Telomere_length against ThalamNuclei rh volume Pc

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0788434	0.1061254	0.4657565
Weighted median	23	-0.0838144	0.0598541	0.1614198
Inverse variance weighted	23	-0.0045712	0.0410717	0.9113795
Simple mode	23	-0.0935278	0.1210317	0.4478910
Weighted mode	23	-0.1101041	0.0735655	0.1486862

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.93572	21	0.2961837
Inverse variance weighted	24.59460	22	0.3168514

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0045603	0.005998	0.4555225

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007457	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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