Two sample MR report

Telomere_length against ThalamNuclei rh volume MGN

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1549972	0.1106405	0.1758459
Weighted median	23	0.0142405	0.0595415	0.8109744
Inverse variance weighted	23	0.0521579	0.0432547	0.2278827
Simple mode	23	-0.0211481	0.1049018	0.8420825
Weighted mode	23	0.0265570	0.0635734	0.6801882

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.01508	21	0.2058748
Inverse variance weighted	27.27824	22	0.2008486

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0063143	0.0062531	0.324094

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008812	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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