Two sample MR report

Telomere_length against ThalamNuclei rh volume MDm

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0746666	0.1002042	0.4644434
Weighted median	23	0.0111657	0.0558397	0.8415113
Inverse variance weighted	23	0.0353036	0.0388455	0.3634450
Simple mode	23	-0.0282753	0.0992570	0.7784084
Weighted mode	23	-0.0125634	0.0668568	0.8526655

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.33847	21	0.4384471
Inverse variance weighted	21.52353	22	0.4886159

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0024169	0.0056633	0.6738966

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006773	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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