Two sample MR report

Telomere_length against ThalamNuclei rh volume MDl

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0059338	0.0994060	0.9529651
Weighted median	23	-0.0215133	0.0552944	0.6972262
Inverse variance weighted	23	-0.0430286	0.0388453	0.2679951
Simple mode	23	0.0185915	0.0959299	0.8481086
Weighted mode	23	0.0185915	0.0736649	0.8030910

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.06161	21	0.5811877
Inverse variance weighted	19.34794	22	0.6237561

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0030063	0.0056182	0.598204

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006235	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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