Two sample MR report

Telomere_length against ThalamNuclei rh volume L-Sg

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0591640	0.1231135	0.6357943
Weighted median	23	-0.0476192	0.0569905	0.4033998
Inverse variance weighted	23	-0.0455857	0.0470196	0.3322934
Simple mode	23	-0.0096712	0.0977374	0.9220733
Weighted mode	23	-0.0140442	0.0713726	0.8458119

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	32.21136	21	0.0557268
Inverse variance weighted	32.23338	22	0.0735032

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0008337	0.0069581	0.905766

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010184	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8