Two sample MR report

Telomere_length against ThalamNuclei rh volume LP

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0096271	0.1547870	0.9509952
Weighted median	23	0.0026294	0.0613791	0.9658296
Inverse variance weighted	23	0.0749728	0.0595900	0.2083396
Simple mode	23	0.0132915	0.1090915	0.9041331
Weighted mode	23	-0.0309977	0.0757685	0.6864137

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	50.91906	21	0.0002714
Inverse variance weighted	51.77393	22	0.0003359

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0051945	0.0087483	0.5590084

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0016811	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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