Two sample MR report

Telomere_length against ThalamNuclei rh volume LGN

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1807505	0.1340752	0.1919801
Weighted median	23	0.0963312	0.0588550	0.1016817
Inverse variance weighted	23	0.0370468	0.0528154	0.4830295
Simple mode	23	0.1080583	0.0948594	0.2668959
Weighted mode	23	0.0784139	0.0658137	0.2461717

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	38.20321	21	0.0121997
Inverse variance weighted	40.66974	22	0.0090191

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0088233	0.0075775	0.2573196

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012599	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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