Two sample MR report

Telomere_length against ThalamNuclei rh volume LD

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0810459	0.1855540	0.6667306
Weighted median	23	0.0153394	0.0571376	0.7883419
Inverse variance weighted	23	0.1013859	0.0708658	0.1525234
Simple mode	23	0.0237912	0.0802378	0.7696229
Weighted mode	23	0.0083748	0.0530185	0.8759292

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	73.17120	21	1e-07
Inverse variance weighted	73.22061	22	2e-07

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0012489	0.0104871	0.9063385

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0024239	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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