Two sample MR report

Telomere_length against ThalamNuclei rh volume CeM

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1217653	0.1053356	0.2606742
Weighted median	23	-0.0421554	0.0555978	0.4483188
Inverse variance weighted	23	-0.0136127	0.0413905	0.7422438
Simple mode	23	-0.0598608	0.1028197	0.5663567
Weighted mode	23	-0.0940437	0.0712444	0.2004008

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.58073	21	0.3138134
Inverse variance weighted	24.97783	22	0.2981361

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0066406	0.0059534	0.2772656

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007606	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8