Two sample MR report

Telomere_length against ThalamNuclei rh volume CM

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0841086	0.1242160	0.5057241
Weighted median	23	0.0522972	0.0576000	0.3639110
Inverse variance weighted	23	0.0159213	0.0478241	0.7391997
Simple mode	23	0.0510250	0.0874475	0.5654960
Weighted mode	23	0.0470790	0.0618656	0.4547434

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	32.79056	21	0.0485916
Inverse variance weighted	33.34589	22	0.0571713

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0041866	0.0070203	0.5573096

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010155	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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