Two sample MR report

Telomere_length against ThalamNuclei rh volume CL

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0060265	0.1809249	0.9737423
Weighted median	23	-0.0145221	0.0546615	0.7904906
Inverse variance weighted	23	0.0762122	0.0694739	0.2726456
Simple mode	23	0.0082353	0.0788512	0.9177652
Weighted mode	23	-0.0291716	0.0583350	0.6219905

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	69.56505	21	4e-07
Inverse variance weighted	70.37282	22	6e-07

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0050494	0.0102255	0.6265662

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0022473	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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