Two sample MR report

Telomere_length against ThalamNuclei rh volume AV

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1431419	0.1537722	0.3624995
Weighted median	23	-0.0330776	0.0569529	0.5613829
Inverse variance weighted	23	0.0249626	0.0606476	0.6806316
Simple mode	23	-0.0279288	0.0854523	0.7468820
Weighted mode	23	-0.0693145	0.0591618	0.2538872

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	50.25147	21	0.0003365
Inverse variance weighted	53.62665	22	0.0001856

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0103215	0.0086908	0.2482368

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.001637	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8