Two sample MR report

Telomere_length against ThalamNuclei lh volume Whole-thalamus

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0169345	0.0994064	0.8663608
Weighted median	23	0.0396702	0.0569664	0.4861919
Inverse variance weighted	23	0.0381065	0.0388454	0.3266035
Simple mode	23	0.0770071	0.0965055	0.4334258
Weighted mode	23	0.0136504	0.0629437	0.8303101

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.36624	21	0.6257244
Inverse variance weighted	18.41978	22	0.6808300

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0013	0.0056182	0.8192568

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005873	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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