Two sample MR report

Telomere_length against ThalamNuclei lh volume VPL

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0523917	0.1218259	0.6715373
Weighted median	23	0.0505995	0.0622225	0.4161014
Inverse variance weighted	23	0.0254256	0.0465761	0.5851390
Simple mode	23	0.1442720	0.0995796	0.1614947
Weighted mode	23	0.1623021	0.0916767	0.0905226

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.54150	21	0.0651062
Inverse variance weighted	31.62835	22	0.0839566

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0016557	0.0068853	0.8122975

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009713	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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