Two sample MR report

Telomere_length against ThalamNuclei lh volume VM

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0458201	0.1218387	0.7106363
Weighted median	23	0.0591571	0.0595623	0.3206141
Inverse variance weighted	23	0.0256914	0.0465526	0.5810309
Simple mode	23	0.0992983	0.0989134	0.3263460
Weighted mode	23	0.0761228	0.0808763	0.3568106

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.54804	21	0.0650083
Inverse variance weighted	31.59643	22	0.0845414

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0012359	0.006886	0.8592827

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009706	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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