Two sample MR report

Telomere_length against ThalamNuclei lh volume VLp

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0754983	0.1100870	0.5003374
Weighted median	23	0.0681428	0.0610878	0.2646402
Inverse variance weighted	23	0.0369091	0.0432441	0.3933789
Simple mode	23	0.0955492	0.1175027	0.4248365
Weighted mode	23	0.0727896	0.0810058	0.3786104

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.75573	21	0.2159164
Inverse variance weighted	27.26490	22	0.2013375

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0069018	0.0062219	0.2798511

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008535	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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