Two sample MR report

Telomere_length against ThalamNuclei lh volume VLa

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1267953	0.0994061	0.2160522
Weighted median	23	-0.0018955	0.0547786	0.9723970
Inverse variance weighted	23	0.0202634	0.0395622	0.6085171
Simple mode	23	0.0545939	0.0883083	0.5427784
Weighted mode	23	-0.0222644	0.0634189	0.7288770

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.23659	21	0.5063228
Inverse variance weighted	22.81957	22	0.4119773

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0090293	0.0056182	0.1229509

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006997	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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