Two sample MR report

Telomere_length against ThalamNuclei lh volume VAmc

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0890171	0.0994063	0.3806766
Weighted median	23	-0.0124466	0.0550874	0.8212459
Inverse variance weighted	23	0.0204422	0.0388455	0.5987189
Simple mode	23	0.0159567	0.0930179	0.8653638
Weighted mode	23	-0.0160741	0.0651453	0.8073958

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.79581	21	0.5982369
Inverse variance weighted	19.35746	22	0.6231635

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0042105	0.0056182	0.4619084

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000595	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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