Two sample MR report

Telomere_length against ThalamNuclei lh volume VA

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2394041	0.1056350	0.0341186
Weighted median	23	-0.0771659	0.0533408	0.1479927
Inverse variance weighted	23	0.0082849	0.0461422	0.8575046
Simple mode	23	-0.0677747	0.0932294	0.4749117
Weighted mode	23	-0.0945768	0.0600174	0.1293387

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.71434	21	0.3071044
Inverse variance weighted	31.04181	22	0.0952632

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0152081	0.0059703	0.0187532

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009419	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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