Two sample MR report

Telomere_length against ThalamNuclei lh volume PuL

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2382525	0.1221841	0.0646594
Weighted median	23	-0.0596768	0.0589450	0.3113399
Inverse variance weighted	23	-0.0058575	0.0511716	0.9088664
Simple mode	23	-0.0891804	0.1078917	0.4173540
Weighted mode	23	-0.0981914	0.0632134	0.1346120

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.72744	21	0.0623746
Inverse variance weighted	38.17811	22	0.0174964

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0142689	0.0069055	0.0513536

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011575	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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