Two sample MR report

Telomere_length against ThalamNuclei lh volume PuI

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0166208	0.1240369	0.8946797
Weighted median	23	-0.0172861	0.0593010	0.7706704
Inverse variance weighted	23	-0.0092025	0.0473610	0.8459364
Simple mode	23	-0.0204614	0.1002408	0.8401343
Weighted mode	23	-0.0418086	0.0681778	0.5460129

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	32.69657	21	0.0496918
Inverse variance weighted	32.70315	22	0.0661734

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0004555	0.0070103	0.9488101

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009927	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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