Two sample MR report

Telomere_length against ThalamNuclei lh volume PuA

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0096425	0.1078234	0.9295884
Weighted median	23	0.0430199	0.0543073	0.4282689
Inverse variance weighted	23	0.0412828	0.0412653	0.3171054
Simple mode	23	0.0955221	0.0819848	0.2564490
Weighted mode	23	0.0722566	0.0637398	0.2691569

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.70712	21	0.2600716
Inverse variance weighted	24.82669	22	0.3054342

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0019427	0.0060939	0.7530317

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007865	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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