Two sample MR report

Telomere_length against ThalamNuclei lh volume Pf

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0164506	0.1503512	0.9139124
Weighted median	23	-0.0155137	0.0561699	0.7824008
Inverse variance weighted	23	0.0117339	0.0574041	0.8380346
Simple mode	23	0.0432760	0.0909110	0.6387487
Weighted mode	23	-0.0049771	0.0575349	0.9318465

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	48.04142	21	0.0006788
Inverse variance weighted	48.04408	22	0.0010706

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0002896	0.0084974	0.973134

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0014584	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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