Two sample MR report

Telomere_length against ThalamNuclei lh volume Pc

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1017773	0.1198435	0.4053189
Weighted median	23	-0.0374688	0.0562035	0.5049875
Inverse variance weighted	23	0.0071398	0.0468048	0.8787579
Simple mode	23	0.0581115	0.0956909	0.5498804
Weighted mode	23	-0.0324024	0.0626600	0.6102356

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	30.52280	21	0.0819748
Inverse variance weighted	31.93968	22	0.0784302

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0066875	0.0067733	0.3347193

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009688	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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