Two sample MR report

Telomere_length against ThalamNuclei lh volume MV(Re)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0504391	0.1208300	0.6805945
Weighted median	23	0.0061945	0.0580205	0.9149761
Inverse variance weighted	23	0.0169586	0.0465336	0.7155321
Simple mode	23	0.1882230	0.1077820	0.0947037
Weighted mode	23	-0.0868184	0.0718299	0.2396223

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.02840	21	0.0731866
Inverse variance weighted	31.57096	22	0.0850106

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0041382	0.006829	0.551027

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009624	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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