Two sample MR report

Telomere_length against ThalamNuclei lh volume MGN

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2862814	0.1245189	0.0318622
Weighted median	23	0.0935156	0.0596684	0.1170553
Inverse variance weighted	23	0.0390460	0.0525436	0.4574111
Simple mode	23	0.1295563	0.0966866	0.1939346
Weighted mode	23	0.1086613	0.0680481	0.1245685

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	32.95211	21	0.0467509
Inverse variance weighted	40.25309	22	0.0100986

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0151801	0.0070375	0.042742

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012502	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8