Two sample MR report

Telomere_length against ThalamNuclei lh volume MDm

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0907708	0.0994066	0.3715409
Weighted median	23	0.0450042	0.0561135	0.4225407
Inverse variance weighted	23	0.0293064	0.0388454	0.4505872
Simple mode	23	0.0743665	0.0892235	0.4135289
Weighted mode	23	0.0428414	0.0607126	0.4878158

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.87089	21	0.5294519
Inverse variance weighted	20.32210	22	0.5628991

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0037739	0.0056182	0.5090824

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006331	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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