Two sample MR report

Telomere_length against ThalamNuclei lh volume MDl

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0667071	0.1144716	0.5662745
Weighted median	23	-0.0079392	0.0605410	0.8956661
Inverse variance weighted	23	0.0216569	0.0438942	0.6217374
Simple mode	23	-0.1248033	0.1093106	0.2658411
Weighted mode	23	0.0137973	0.0816514	0.8673580

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.84853	21	0.1444997
Inverse variance weighted	28.09094	22	0.1726870

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0027661	0.0064697	0.6733349

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008606	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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