Two sample MR report

Telomere_length against ThalamNuclei lh volume L-Sg

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0515362	0.1003960	0.6130797
Weighted median	23	-0.0383260	0.0570030	0.5013604
Inverse variance weighted	23	-0.0341686	0.0391075	0.3822767
Simple mode	23	-0.1609627	0.1119602	0.1645981
Weighted mode	23	-0.0577446	0.0780697	0.4673293

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.42084	21	0.4335147
Inverse variance weighted	22.29816	22	0.4422171

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0052623	0.0056742	0.3642512

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006991	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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