Two sample MR report

Telomere_length against ThalamNuclei lh volume LP

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0373693	0.1451091	0.7992797
Weighted median	23	0.0925412	0.0632513	0.1434477
Inverse variance weighted	23	0.0915216	0.0556180	0.0998589
Simple mode	23	0.0958819	0.1195383	0.4310737
Weighted mode	23	0.0958819	0.0906131	0.3014699

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	44.75164	21	0.0018667
Inverse variance weighted	45.10191	22	0.0025760

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.003325	0.0082013	0.6892693

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0015348	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8