Two sample MR report

Telomere_length against ThalamNuclei lh volume LGN

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0977444	0.1549028	0.5348456
Weighted median	23	-0.0461154	0.0596202	0.4392345
Inverse variance weighted	23	-0.0242650	0.0601627	0.6867103
Simple mode	23	0.0845702	0.1251299	0.5061733
Weighted mode	23	-0.0240078	0.0644312	0.7130029

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	50.99462	21	0.0002648
Inverse variance weighted	52.77265	22	0.0002443

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0074913	0.0087546	0.4018269

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0016108	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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