Two sample MR report

Telomere_length against ThalamNuclei lh volume LD

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1209696	0.1349318	0.3801357
Weighted median	23	0.0445560	0.0610751	0.4656792
Inverse variance weighted	23	0.0311575	0.0521526	0.5502213
Simple mode	23	0.0482181	0.0923907	0.6069594
Weighted mode	23	0.0482181	0.0597925	0.4286297

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	38.6921	21	0.0106800
Inverse variance weighted	39.6555	22	0.0118578

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0055144	0.007626	0.4775914

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012209	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8