Two sample MR report

Telomere_length against ThalamNuclei lh volume CeM

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0687617	0.1174670	0.5645371
Weighted median	23	-0.0115847	0.0552656	0.8339656
Inverse variance weighted	23	0.0199875	0.0455616	0.6608855
Simple mode	23	0.0644682	0.1050327	0.5456476
Weighted mode	23	-0.0491249	0.0693849	0.4863759

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.32486	21	0.1064181
Inverse variance weighted	30.26562	22	0.1121500

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0054492	0.006639	0.4209871

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009251	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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